40+ is 100% EstroG-100™, a patented formulation of three herbal extracts that have been used for hundreds of years. It has been the subject of three scientific studies on menopause. It naturally supports the body’s natural response to hormonal changes including normal body temperature, mood, healthy joints, energy levels, and restful sleep.
Perimenopause, the first stage of menopause, usually starts in a woman’s 40s, but can start in her 30s or even earlier. 40+ is recommended for use at the first signs of perimenopause through to post-menopause.
- Natural herbal formulation
- Scientifically researched to support women in all stages of menopause
- No side effects
- Presented in VEGE capsules – suitable for vegetarians and vegans
Many women experience support within four weeks, but we recommend allowing 12 weeks and continuing use daily for ongoing maintenance.
Always read the label and use as directed. If symptoms persist see your healthcare professional.
40+ comprises pure EstroG-100™ – a patented formulation that has been the subject of three published scientific studies on menopause. It combines the roots of three herbs: Cynanchum wilfordii (Milkweed), Phlomis umbrosa (Jerusalem sage) and Angelica gigas nakai (Angelica).
Cynanchum are climbing vines, Phlomis are sage-like herbs and Angelica is used as a food, herbal remedy and flavour. These herbs have been used for hundreds of years as culinary herbs in Korea and have a long history of use.
It is the proprietary blend of these three synergistic herbs that provides the efficacy for women in all stages of menopause.
Phlomis umbrosa is wild harvested, while Cynanchum wilfordii and Angelica gigas nakai are cultivated.
What is EstroG-100™ (the ingredient in 40+)?
EstroG-100™ is a proprietary standardised herbal ingredient that supports hormonal balance and supports women in pre-, peri-, and post-menopause.
How was EstroG-100™ discovered?
Dr Jae Kim, the inventor, is a Korean medical doctor who studied these plants for many years. Dr. Kim developed some screening tests to find out which plant extracts had the best efficacy and least side effects. He screened 71 different extracts with his E-screen assay before finding the best combination. The EstroG-100™ combination was the best at supporting estrogenic activity and estrogen specific alkaline phosphatase (ALP) induction.
Does EstroG-100™ contain estrogen?
No, EstroG-100™ does not contain any estrogen properties or well-known phytoestrogens such as coumestans, isoflavones, genistein, daidzein, biochanin A and formononectin. Unlike all the other herbal ingredients for menopause, EstroG-100™ does not bind to estrogen receptors alpha and beta and it does not proliferate MCF-7 cells. In addition, in contrast to other phytoestrogen products, EstroG-100™ was confirmed not to affect FSH/E2, uterus weight, BMI and body weight.
If EstroG-100™ contains no phytoestrogens, then how does it work? What is its mode of action (MOA)?
The available scientific evidence suggests the mechanism of action for EstroG-100™ supporting menopausal balance and bone metabolism is due to its support for a selective estrogen receptor modulator (SERM). Certain plant compounds in EstroG-100™ support balanced estrogen metabolism. This works in harmony with your own body’s metabolic and biochemical pathways.
Can I expect better or faster results with a higher dose?
The published scientific studies all used the same dose of EstroG-100™. However, we have anecdotal evidence from many years of usage that showed some women had benefitted by taking EstroG-100™ more frequently.
Why is EstroG-100™ called a proprietary herbal ingredient?
EstroG-100™ is patented in the USA, Canada, Japan, China, Australia, New Zealand, Russia, and is soon to be patented in EU, Brazil, Mexico and other Asian countries. This means it is proprietary, and you can only get EstroG-100™ from the licensee who is Meno-Me® Ltd in New Zealand.
Who should not take 40+?
Pregnant or lactating women and those taking anti-thrombotic or anti-coagulant* products should consult your health practitioner before taking EstroG-100™.
*There have been no reported interactions or side-effects when taking anti-thrombotics or anti-coagulants while on MenoMe® 40+ or the active ingredient EstroG-100™. However, one of the herbs, Angelica, is known to have anti-coagulant and anti-thrombotic effects when taken in higher doses. Therefore in Korea, the Food and Drug Administration requires that there should be an advisory statement on health functional foods containing Angelica. This advisory is not required in other countries, including New Zealand (where it is regulated as a dietary supplement) and Canada, (where it is registered as a Natural Health Product).
How is it best to take 40+?
Take two capsules daily. It is important to take 40+ daily to get the best results.
How long does it take?
This varies with individuals (thankfully we are all different!) – but based on our scientific research, you can expect to notice support within six weeks. However, based on our experience, it can take from one to four weeks. The fastest case we know of was within two days! Optimum results are usually reached within 12 weeks.
What can I expect when taking 40+?
Every woman is different. The effects can be dramatic for some and more subtle for others, with reports of an overall sense of calmness occurring. We recommend that you keep taking 40+ throughout your perimenopause even if the effects fluctuate at times. This will enhance a more balanced hormonal experience during your menopausal journey compared to not taking 40+.
How long should I take 40+ for?
It is advisable to keep taking 40+ throughout your perimenopause. Once your periods have stopped for 12 continuous months you are officially in post-menopause at which stage we recommend you switch to 55+.
Why do I experience fluctuations, even when I am taking 40+?
Everything in nature has rhythms and cycles – peaks and troughs. There is no stronger example of the peaks and troughs in our body chemistry than a woman’s monthly cycle. Some women will experience much higher peaks and lower troughs than others, and will therefore have more severe experiences than others.
40+ supports balance for these peaks and troughs, but will not eliminate them to a flat line. This is because of the way 40+ and 55+ work; to help balance your own natural hormone levels. 40+ does not contain estrogens but works to support your own naturally produced hormones. As such it will smooth but not completely flatten the cyclic rhythm. This is the most natural way to manage your menopause and results in outstanding quality of life scores when measured in our scientific research.
Are there any possible adverse reactions from 40+?
There were no noted adverse reactions during the scientific studies. However, there may be a temporary itching or rash on the skin for people who are sensitive to taking new materials. 40+ helps purify the bloodstream, and urticarial (skin rash/hives) may very rarely occur due to the detoxification process. Should this happen reduce the dose to one capsule per day, or every second day. If symptoms persist stop taking for a week and then resume.
Is 40+ suitable for women with endometriosis?
40+ does not have estrogen activity and has not been specifically tested for safety or efficacy for endometriosis. However, in the menopause scientific studies, endometriosis was not a requirement for the exclusion of participants in the trials. Only patients with cervical cancer, endometrial cancer, breast cancer, and sex hormone-related cancers were excluded.
Is 40+ suitable for women who have under-active thyroid?
EstroG-100™ (the ingredient in 40+) has not been shown to affect thyroid function, but no studies have been conducted to prove safety for women with an underactive thyroid. However, in scientific studies for menopause, subjects with thyroid disease participated where their medical practitioner judged them suitable.
Can you take 40+ together with other supplements?
Yes. There are no known interactions with 40+.
Can you take 40+ together with other medicines?
If you are taking anti-thrombotic or anticoagulant medications consult with your doctor before taking 40+.
Can men take 40+?
There is no harm in men taking 40+ but there is no evidence it will assist them in any way.
How should I store 40+?
Keep in a cool dry place, away from direct sunlight and moisture.
What is the shelf life for 40+?
40+ is shelf-stable for three years (36 months).
Where can I purchase 40+?
40+ is sold exclusively from our website www.meno-me.co.nz.