The Science

Smart Science

We combine the ancient wisdom of Asian traditional medicine with state of the art science using a patented blend of botanical root extracts, New Zealand plant extracts and powerful vitamins and minerals.

MenoMe® Offers Natural Menopause Solutions.
Safe. Effective. Scientifically Proven.
Tested On Humans.

Ever since MenoMe® was founded in 2015 we’ve been driven by the scientific study of safe, effective, natural ingredients. We look at their synergy with the biochemistry of the human body to help women navigate the biological changes of perimenopause through to the rest of their lives in post-menopause.

From biotech laboratories in Asia to cutting edge science and innovation down under we have uncovered some of the safest ingredients and formulations. We’ve ensured they’ve been through scientific testing and human trials, have no known adverse side effects, are estrogen, hormone and black cohosh free*. As well as this they contain no artificial flavours, colours, preservatives or fillers, and are plant-based and vegetarian friendly.
(*Black cohosh has been linked to liver toxicity in a few cases.)

At MenoMe®, we understand that some women feel they’ve tried everything without success. We know many of them feel short-changed by a scarcity of knowledge when they ask for help. We’re also aware a large percentage of women would like to manage their menopause naturally without prescription medications.

As a female-led organisation, we’ve walked this path ourselves. To be clear, not every woman will experience symptoms during their menopausal years. Our mission is to help those women who find themselves struggling with the common signs. It’s our aim is to offer safe solutions and a strong community of support and credible information.



A long history of use in traditional medicine and years of research and development have gone into the formulation of EstroG-100™. This is the patented herbal root blend we use in both 40+ and 55+.



40+ and 55+ are completely natural. We use vege capsules and NO artificial flavours, artificial colours, preservatives or fillers.


Estrog-100™, the herbal extract in 40+ and 55+ has been through several clinical trials. Enzogenol®, the pine bark extract we use in 55+ is backed by scientific research. We also use marine magnesium and vitamin D3 in 55+ – both well-known, proven supplements.

Table of Contents

All about 40+ ingredients


EstroG-100™ is a proprietary standardised novel phytoestrogen.

Dr Jae Kim, the doctor who formulated EstroG-100™ screened 71 herbal extracts. Out of these, he chose three to make up the blend: cynanchum wilfordii, phlomis umbrosa, and angelica gigas nakai. The trio have a rich history in Korea and China with 400 years of documented use as folk medicine. Their proven safety record has seen them registered as safe food ingredients in the Korean food codex and in China.

Cynanchum Wilfordii

Known as Baeksu-o in Korea, cynanchum wilfordii means ‘white hair becomes black again’. The roots have been used for hundreds of years as a traditional herbal treatment for women’s health. Cynanchum wilfordii is classified as a raw material for food by the Korean Food and Drug Administration. As such it’s been shown to improve cardiovascular health, enhance vitality, boost the immune system, epithelial function, and protect the liver and corticol neurons.

Phlomus Umbrosa

Phlomis umbrosa is a herbal root extract known as sokdan in Korea which means ‘reconnecting something discontinued’. It has been used for women’s health and as a detoxification aid for thousands of years. In addition, phlomus umbrosa has been shown to discourage mast cell secretions and histamine.

Angelica gigas Nakai

Known as dangui in Korea, which means ‘going back to the normal state’ angelica gigas nakai has historically been used as a women’s health remedy. Also known as ‘female ginseng’ it regulates estrogen levels and is one of the more studied herbs used in EstroG-100™. Angelica gigas nakai has been found to be beneficial in the treatment of insomnia, heartburn, arthritis, nervousness, cognition, inflammation, blood circulation issues and as a tonic for anemia.

All about 55+ ingredients

55+ contains EstroG-100™, Enzogenol®, Vitamin D3 and Marine Magnesium.


As explained here under 40+ ingredients section.


Enzogenol® is a pine bark extract. It comes from the bark of New Zealand Pinus Radiata trees that grow in the Kaingaroa forest near Taupo. Taupo is in the middle of the North Island of New Zealand.

During the making of Enzogenol®, a pure water extraction process is used. This makes a concentrated extract packed full of health benefits. Enzogenol® is 100 percent natural and only water and pine bark are used in the process.

Proanthocyanins (pacs)
The pine bark contains a number of flavonoids that make it a potent antioxidant with anti-inflammatory and neuroprotective properties. Eighty percent of the flavonoids are from a group known as proanthocyanins (pacs). Pacs are also found in fruits, vegetables, red wine, dark chocolate and tea.

The super-powered antioxidant activity of Enzogenol® is important because oxidative damage in our bodies is behind many diseases. These include cancer, heart disease, Alzheimer’s and ageing. Enzogenol®’s antioxidant activity has the power to neutralise the free radicals thought to be a major cause of the aforementioned conditions and ageing. Proanthocyanins have also been shown to reduce chronic inflammation associated with conditions such as cardiovascular disease, metabolic syndrome, hypertension and diabetes.

Healthy Brain, Healthy Gut
Enzogenol® has been found to be extremely beneficial for healthy brain function particularly as we grow older. It was also shown to help restore gut health and reduce oxidative stress and irritation of the gut walls. Pacs act as prebiotics reducing the growth of harmful gut bacteria.

Enzogenol® has an excellent safety profile with no known interactions with other medications

Vitamin D3

Vitamin D3 is the same form of vitamin D that our bodies naturally make from sunlight. Also known as cholecalciferol it’s important for skeletal strength and one of its main roles is to help with the absorption and optimum functioning of calcium by the body. A lack of vitamin D may increase our risk of weakened bones and osteoporosis. Vitamin D3 is derived from the fat in sheep wool (without causing harm to the animal).

Learn More

Marine Magnesium

Magnesium is a calming mineral and helps optimise the work of vitamin D3. It also has many other important roles and is essential for bone, brain, muscle and nerve health as well as being an essential component of our DNA. Magnesium is beneficial to blood pressure, insulin metabolism and energy levels. Low levels of magnesium are associated with headaches, Alzheimer’s disease, hypertension, cardiovascular disease and Type-2 diabetes.

The marine magnesium we use in 55+ is known as Aquamin and comes from the cytoskeleton of red algae. During this aquatic plants life, it accumulates minerals from the seawater which is stored as carbonate salts in the plant. Sourced from clean waters off the coastline of Iceland, it’s a natural form of highly absorbable magnesium – magnesium hydroxide. Other than washing and milling, Aquamin is unaltered from the raw material. As a result it represents a natural multi-mineral material that has FDA GRAS certification.

Bioaccessibility and Bioavailability of a Marine-Derived Multimineral, Aquamin-Magnesium

Clinically proven

EstroG-100™, the hormone balancing ingredient in 40+ and 55+ has been clinically proven to help alleviate symptoms of menopause. Enzogenol®, (pine bark extract) used in 55+ has also been clinically proven to help with brain health. Marine magnesium and vitamin D3 also in 55+ – are both well-known, evidence-backed supplements.

What does it mean to be Clinically Proven?

"We often hear medical professionals advising us not to take supplements that do not have evidence of efficacy (effectiveness). Usually, they describe this in words such as “clinically proven” or “having undergone clinical trials”. The reason is that medical practitioners are concerned about the health, safety and welfare of their patients. They see too many examples of patients taking both medicines and supplements that, at best will have no tangible benefit. Or, at worst could actually be harmful."

Peter Lehrke - Nutritional Biochemist

In essence clinically proven means that a product has been through controlled scientific testing and shown positive results. The testing is usually done in a laboratory setting and/or in human studies that measure safety and efficacy. Strict controls and in-depth statistical analysis are an essential part of the results.

Estrog-100™ Clinical Study Extracts

The Effect of Herbal Extract (EstroG-100™) on Pre-, Peri- and Post-Menopausal Women: A Randomized Double-blind, Placebo-controlled Study

Evaluation of Effectiveness and Safety of Natural Plants Extract (Estromon®) on Perimenopausal Women for 1 Year

Angelica gigas Nakai – links to trials:

Neuroprotective and Cognitive Enhancement Potentials of Angelica gigas Nakai Root: A Review

Ultrafine Angelica gigas Powder Normalizes Ovarian Hormone Levels and Has Antiosteoporosis Properties in Ovariectomized Rats: Particle Size Effect

Effects of Angelica gigas Nakai as an Anti-Inflammatory Agent in In Vitro and In Vivo Atopic Dermatitis Models

Neuroprotective and Cognitive Enhancement Potentials of Angelica gigas Nakai Root: A Review

Proven to alleviate 10 of the 12 main symptoms of menopause

Diagram showing improvement of menopause symptoms

Mechanism of Action

As stated previously we use a well-researched and clinically proven trio of herbs known as EstroG-100™ in 40+ and 55+ to balance estrogen. EstroG-100™ stems from Traditional Chinese Medicine and Korean herbal tradition.

More correctly we use the powdered root extract of these herbs. They include a sage variety, a type of Angelica which has been used for culinary purposes as well as herbal medicine for hundreds of years and a variety of climbing vine known as milkweed.

Their technical names are:

  • Cynanchum wilfordii (Milkweed),
  • Phlomis umbrosa (Jerusalem sage) and
  • Angelica gigas nakai (Angelica)

How do they work for perimenopausal and post-menopausal symptoms?

Many of the symptoms of perimenopause and post-menopause are due to either fluctuating or diminished levels of estrogen. Common signs are hot flushes, sleep disruption, insomnia, nervousness, anxiety, cardiac symptoms, rheumatic pain, fatigue and cognitive and memory changes.

It’s technical, but EstroG-100™ has an indirect action – as opposed to most treatments which act directly – on estrogen receptor function. Receptors are proteins in cells – we have estrogen receptors all over our bodies (not just our ovaries). These specific receptors are activated by estrogen for a number of different reasons.

EstroG-100™ acts like what is known as a selective estrogen receptor modulator (SERM) to support balanced estrogen metabolism. The SERM action works with our bodies own biochemistry to regulate estrogen gently, naturally and safely.

The mechanism of SERM also supports bone density and human growth hormone levels. This helps protect against loss of bone density, osteoporosis and the risk of cardiovascular conditions.

Quality of Life

Scientific testing demonstrated that EstroG-100™ significantly improved at least 10 different symptoms of perimenopause and menopause. These included hot flushes, paresthesia, nervousness, melancholia, vertigo, fatigue, rheumatic pain, formication and vaginal dryness.

No severe adverse effects or change of body weight were reported and there was an improvement on the Kupperman Menopause Index (KPI). The KPI scale measures quality of life.

Kupperman Diagram

Enzogenol® Clinical Studies

Enzogenol® has been through two randomised controlled nutrition trials. These were conducted at Auckland University of Technology and the Brain Sciences Institute at Swinburne University in Melbourne.

Links to trials

Chemical Composition

Safety & efficacy

Scientific studies support safety

Numerous studies have been conducted on a standardised combination of cynanchum wilfordiiphlomis umbrosa and angelica gigas nakai.

The blend has been tested in several toxicological studies without any negative results. In a 2016 study published in Toxicological Research, this botanical blend did not exhibit any estrogenic activity at any tested concentrations.

Additional data from a 26-week toxicity study, conducted in a GLP accredited laboratory, support the safety of the herbal combination at a daily dosage of 514 mg per day.

Clinical research demonstrates efficacy

A 12-week, multicentre, double-blind, randomised, placebo-controlled clinical trial was conducted by researchers from Ajou University Medical Center, Korea University Anam Hospital and Yonsei University College of Medicine Severance Hospital in Seoul and Suwon, Korea. Ninety-six female participants between the ages of 40 and 70 with menopausal symptoms were given 514 mg of a blend of cynanchum wilfordii, phlomis umbrosa and angelica gigas daily for 12 weeks.

The study demonstrated significant improvement in at least nine different symptoms of perimenopause and menopause, including hot flushes, paresthesia, nervousness, melancholia, vertigo, fatigue, rheumatic pain, formication and vaginal dryness.

No severe adverse events were reported. Additionally, there was no significant change in body weight, serum hormone levels or endometrial thickness.

Another study conducted by the Samsung Cheil Hospital School of Medicine at Sungkyungwan University in South Korea evaluated the administration of cynanchum wilfordii, phlomis umbrosa and angelica gigas, along with vitamins and minerals.

In this randomised, double-blind, placebo-controlled study, the treatment group showed significant improvement in menopausal symptoms — about five times more than the placebo group.

A human study conducted at the Friends Medical Group (California, USA) showed significant improvement according to the Kupperman Menopause Index. Ten common menopausal symptoms, including hot flushes, insomnia, nervousness, depression, vertigo, fatigue and vaginal dryness were improved. There was no significant change in body weight or mass compared with the placebo group.


In a 2008 animal study, ovariectomised animals showed significant improvement in bone mass density when treated with a combination of the three above extracts for 12 weeks. Human trials have also shown impressive results, increasing bone mass while relieving menopausal symptoms. In 2005, a prospective randomised clinical trial was performed on 48 perimenopausal women who visited Samsung Cheil hospital. Half were given a placebo and half were given a combination of the three extracts twice a day for twelve months. Bone mass density, serum bone markers, weight, body mass index, serum lipid profile, human growth hormone, follicle-stimulating hormone (FSH) and estrogen were measured at the beginning of the trial and at 3, 6, 9 and 12 months. Hormones are measured because during perimenopause estrogen levels fluctuate and FSH remains elevated. By the time menopause itself hits, estrogen and FSH are both low.

In the group taking the herbal extract, there was significantly improved bone density in the femur, higher blood levels of human growth hormone, and improved levels of triglycerides, compared to the control group. This is particularly notable because regular hormone replacement therapy (HRT) often increases triglycerides. Total cholesterol, body mass index, blood levels of estrogen and follicle-stimulating hormone remained unchanged in both groups. Low density and high-density lipoprotein (LDL and HDL) also remained unchanged in both groups. Again, HRT often leads to changes in these markers.

Unpleasant symptoms of menopause were markedly improved in the treatment group. A remarkable 57 percent of the study group felt relief from perturbing symptoms such as hot flashes, dyspareunia, sleep disorders, and fatigue by three months, while slightly less than 17 percent of the control group had relief.

In a 2011 follow-up study, the same blend of three extracts was studied on 64 pre-, peri-and post-menopausal women. The Phase II double-blind, placebo-controlled safety study recruited patients from two medical practices in California and lasted for three months. Women were carefully selected and were not allowed to participate if they had a suspicion of breast or endometrial malignancy, a personal or family history of breast cancer, a history of using estrogen or progestin-containing products in the prior three months, or other ailments such as uncontrolled hypertension, drug use, excessive weight or diabetes.

Changes in the Kupperman menopause index (KMI), vaginal dryness, insomnia, nervousness, vertigo, and fatigue were all measured. The mean KMI score was significantly reduced in the group receiving the herbal extract, the constitutional and vasomotor symptoms were significantly improved, and there was a statistically significant improvement in vaginal dryness. During this three month period, there was not any significant weight gain or other serious adverse effects. In fact, the authors note that “There were no significant changes in body weight, BMI, serum E2 (estradiol) levels, serum FSH levels, or liver enzymes, all of which have previously been observed with hormone replacement. therapy.


Links to other studies:

Safe for Breast Cancer Patients

During clinical trials, EstroG-100™ showed an inhibition of proliferation of human breast cancer cells (mcf-7) and no binding affinity to estrogen receptors er a and er β. It has been through acute, multi-dose and genetic toxicity tests which have shown it to be safe for breast cancer patients.

MenoMe safe for breast cancer survivors

Increased Bone Density

Another positive benefit included an increase in bone mass density when taking EstroG-100™ for 12 weeks.

Clinical studies show that EstroG-100™ has no estrogenic effect and, unlike hormone replacement therapy, it does not affect weight or body mass index.

Improved Skin Hair and Nails

MenoMe helps skin hair and nails graph
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This is the time when menstruation is well and truly over, the ovaries have stopped producing high levels of sex hormones and for many ladies, perimenopause symptoms subside.

Estrogen has protective qualities and the diminished levels mean organs such as your brain, heart and bones become more vulnerable. It’s also a key lubricant so your lips may become drier, your joints less supple and your vagina might be drier. In addition, your thyroid, digestion, insulin, cortisol and weight may alter.

At this juncture, a woman might experience an increase in the signs of reduced estrogen but she should have a decrease of perimenopause symptoms. That said, some women will experience symptoms like hot flushes for years or even the rest of their lives.


Peri = ‘near’

Most females begin to experience the symptoms of perimenopause in their mid-forties. Your progesterone levels decline from your mid-30s but it’s generally from around 40 that the rest of your sex hormones begin to follow suit. 

Perimenopause is a different experience for every woman and some women may barely notice it. The first indicators are usually changes to the monthly cycle. This means that for some ladies, this can be accompanied by things like sore breasts, mood swings, weight gain around the belly, and fatigue as time goes on.

For those with symptoms it can be a challenging time physically, mentally and emotionally.

Importantly, perimenopause lasts – on average – four to 10 years. The transition is usually a gradual process and many women enter perimenopause without realising.