What Is Enzogenol®?

Radiata Pine

Enzogenol® is one of the main players in 55+ and it’s an enormously exciting supplement.

The more research it undergoes, the more benefits it’s shown to have.

The reason we’ve included it in 55+ is that – at any stage of life but most particularly post-menopause – our brain, heart, and overall health need super duper support and we discovered that Enzogenol® is a perfect partner to this end.

Where does Enzogenol® come from?

Enzogenol® is a plant extract derived from the bark of New Zealand radiata pine trees. It’s extracted using an environmentally friendly water-only process.

Radiata Pine Bark
Image courtesy of Enzo

What are the properties of Enzogenol®?

Enzogenol® contains more than 80 per cent proanthocyanidins. You’ve no doubt heard of the polyphenols in green tea? There’s been lots of info about the powerful antioxidant benefits of polyphenols floating about the place. Well, proanthocyanidins are a type of polyphenol. They’re also potent antioxidants and are rich in bioflavonoids so they’re anti-inflammatory. This is extremely relevant to Meno-She’s as inflammation can exacerbate the symptoms of peri/menopause.

In fact, the antioxidant effect of Enzogenol® was tested on the ORAC scale and has been rated higher than vitamin C and grape seed extract.* The ORAC score is a method developed by scientists at the US National Institute of Health and Aging (NIH) to measure the antioxidant capacity of certain foods.

Radiata Pine
Image courtesy of Enzo

A Short Lesson On Free Radicals & Antioxidants

Antioxidants are crucial to our health and to reduce cellular damage. As we age, and as we’re exposed to more and more toxins, stress and ill health, free radicals are formed. Free radicals are like little gremlins that have the ability to cause loads of damage in our bodies and create oxidative stress. Any wellness pro will recommend loading up with antioxidants because they have the ability to neutralise free radicals.

Oxidative stress is a major player in the formation and progression of disease. It also plays an important role in the ageing process. During oxidative stress, the body can be overwhelmed by the production of free radicals, which can damage cell molecules and destroy cellular function. This can lead to increased inflammation and loss of organ function, which contributes to chronic disease, ageing and the destruction of organs and tissues.

Are you with me so far? I’m trying to keep it as simple as possible because the science-y stuff can cause cases of eye glazing – lol 😀

What Are The Benefits Of Taking Enzogenol®?

Radiata Pine NZ
Image courtesy of Enzo

There are still lots of studies going on but in the research to date – for our purposes – Enzogenol ® has been shown to support brain, heart and eye health.

Brain Health

Enzogenol® has been found to be beneficial to the brain particularly in relation to memory and cognition. One of the studies also showed it has a calming effect (we like that).

Heart Health

Nutritional research has shown that when it comes to cardiovascular health Enzogenol® supports healthy blood vessels, blood viscosity and blood pressure.


You’ve heard of telomeres? They sit on the ends of chromosomes and look similar to the cap ends of shoelaces. These ‘caps’ shorten with age and some studies are showing that Enzogenol® can reduce the occurrence of this.

Overall Benefits

All in all, the compounds in Enzogenol® are on a par with the wonderful health benefits of a whole foods plant-based diet packed with fresh fruits, green leafy vegetables, nuts and seeds. So by supplementing with it daily, you’re donning a suit of armour. Happy dance! 💃🏽💃🏽💃🏽

Happy Dance
Photo by Mohamed Nohassi on Unsplash

Great News!

Isn’t that great news for Meno-She’s? Especially those of us who are forgetting why we’ve walked into a room or feel bouts of frequent brain fog! And a calmer brain sounds like heaven to me. I don’t know about you but improvements in cognition and alertness are definitely on my wishlist.

The antioxidant power is something to be revered too. Remember the little lesson we had in free radicals and oxidative stress? Those things attack our DNA, but antioxidants can act like the defence warriors and battle with them. And the more protected our DNA is the healthier we are.

55+ 120s subscription

And that’s exactly why we’ve included Enzogenol® in 55+. Which you can get here. Immediately. 😀


Study Information:

*Enzogenol® was tested at the independent US Brunswick Laboratories using the popular ORAC (oxygen radical absorbance capacity) assay. The ORAChydroFL assay measures the ability of an antioxidant to scavenge superoxide radicals in the aqueous phase. The ORAChydroFL value for Enzogenol was established as 8974 µmol Trolox Equivalents/g

Brain function:

Dr.Andrew Pipingas and Prof. Richard Silberstein at the Brain Sciences Institute, Swinburne University of Technology, and Melbourne, Australia studied the effects of Enzogenol® on brain function in a randomised controlled trial

The study also investigated how Enzogenol® may affect brain electrical activities and interactions between brain regions. Analyses showed that Enzogenol® led to unique changes in brain activities indicating enhanced cognitive processing in the Enzogenol® group with brain patterns of increased calmness and improved focus and concentration.

The effects of Enzogenol® on brain function were published in the following peer-reviewed research articles:
Pipingas, A., Silberstein, R. B., Vitetta, L., Rooy, C. V., Harris, E. V., Young, J. M., Frampton, C. M., Sali, A., Nastasi, J., 2008. Improved cognitive performance after dietary supplementation with a Pinus Radiata bark extract formulation. Phytotherapy Research 22, 1168-1174.

Eye Health

The effects of Enzogenol® on parameters of eye health were studied in a randomised controlled trial by Dr Nigel Gilchrist of the Christchurch Geriatric Medical Research Trust at the PrincessMargaret Hospital, Christchurch, New Zealand.

Cardiovascular Health

Clinical research in generally healthy, older volunteers have shown that taking an Enzogenol® formulation for 12 weeks can improve several parameters of cardiovascular health. Endothelial function, a measure for the elasticity and overall health of blood vessels, significantly improved, and average systolic blood pressure was reduced from 130 to 123 indicating that Enzogenol® further improved the cardiovascular measures in the healthy volunteers.

  • Wood, J. E., Senthilmohan, S. T., & Peskin, A. V. (2002). Antioxidant activity of procyanidin-containing plant extracts at different pHs. Food Chemistry, 77(2), 155-161
  • [1] de la Iglesia, R., Milagro, F. I., Campión, J., Boqué, N., & Martínez, J. A. (2010). Healthy properties of proanthocyanidins. Biofactors, 36(3), 159-168.

Sign up to our mailing list for the latest news and stories and receive a $5 discount code to redeem on your first 40+ or 55+ purchase, plus receive a 3 step eBook on how to minimise your menopause symptoms. Click here